Ilya Okun : rechercher sur Z-Library

Dmitri V. Kravchenko, Vladimir V. Kysil, Alexey P. Ilyn, Sergey E. Tkachenko, Sergey Maliarchouk, Ilya M. Okun, Alexandre V. Ivachtchenko

Année:

2003

Fichier:

PDF, 50 KB

2003

1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as Potent Caspase-3 Inhibitors.

Journal:

Alexandre V. Ivachtchenko, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya M. Okun, Volodymyr M. Kysil

Année:

2005

Fichier:

PDF, 21 KB

2005

ChemInform Abstract: 8-Sulfonyl-Substituted Tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 Receptor Antagonists.

Journal:

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Angela G. Koryakova, Oleg D. Mitkin, Sergey E. Tkachenko, Volodymyr M. Kysil, Ilya Okun

Année:

2010

Fichier:

PDF, 19 KB

2010

ChemInform Abstract: 2-Substituted 5,6-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: New Series of Highly Potent and Specific Serotonin 5-HT6 Receptor Antagonists.

Journal:

Année:

2011

Fichier:

PDF, 22 KB

2011

Halogen substitution at the isoxazole ring enhances the activity of N-(isoxazolyl)sulfonamide endothelin antagonists

Ming Fai Chan, B. Raju, Adam Kois, Rosario S. Castillo, Erik J. Verner, Chengde Wu, Emily Hwang, Ilya Okun, Fiona Stavros, V.N. Balaji

Journal:

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Angela G. Koryakova, Sergiy M. Kovalenko, Oleg D. Mitkin, Ilya M. Okun, Irina M. Ravnyeyko, Sergey E. Tkachenko, Oleg V. Zaremba

Année:

1996

Langue:

english

Fichier:

PDF, 257 KB

english, 1996

Synthesis and biological study of 3-(phenylsulfonyl)thieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidines as potent and selective serotonin 5-HT6 receptor antagonists

Journal:

Angela G. Koryakova, Yan A. Ivanenkov, Elena A. Ryzhova, Elena A. Bulanova, Ruben N. Karapetian, Olga V. Mikitas, Eugeny A. Katrukha, Vasily I. Kazey, Ilya Okun, Dmitry V. Kravchenko, Yan V. Lavrovsky

Année:

2010

Langue:

english

Fichier:

PDF, 511 KB

english, 2010

Novel aryl and heteroaryl substituted N-[3-(4-phenylpiperazin-1-yl)propyl]-1,2,4-oxadiazole-5-carboxamides as selective GSK-3 inhibitors

Journal:

Alexandre V. Ivachtchenko, Eugene B. Frolov, Oleg D. Mitkin, Volodymyr M. Kysil, Alexander V. Khvat, Ilya M. Okun, Sergey E. Tkachenko

Année:

2008

Langue:

english

Fichier:

PDF, 212 KB

english, 2008

Synthesis and biological evaluation of novel γ-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists

Journal:

Alexandre V. Ivachtchenko, Eugen B. Frolov, Oleg D. Mitkin, Sergei E. Tkachenko, Ilya M. Okun, Alex V. Khvat

Année:

2009

Langue:

english

Fichier:

PDF, 457 KB

english, 2009

Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles

Journal:

Alexandre V. Ivachtchenko, Dmitri E. Dmitriev, Elena S. Golovina, Elena S. Dubrovskaya, Madina G. Kadieva, Angela G. Koryakova, Volodymyr M. Kysil, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya M. Okun, A

Année:

2010

Langue:

english

Fichier:

PDF, 379 KB

english, 2010

Synthesis of cycloalkane-annelated 3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines and their evaluation as 5-HT6 receptor antagonists

Journal:

Dmitri V. Kravchenko, Volodymyr M. Kysil, Sergey E. Tkachenko, Sergey Maliarchouk, Ilya M. Okun, Alexandre V. Ivachtchenko

Année:

2010

Langue:

english

Fichier:

PDF, 638 KB

english, 2010

Pyrrolo[3,4-c]quinoline-1,3-diones as potent caspase-3 inhibitors. Synthesis and SAR of 2-substituted 4-methyl-8-(morpholine-4-sulfonyl)-pyrrolo[3,4-c]quinoline-1,3-diones

Journal:

European Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 321 KB

english, 2005

Thiophenesulfonamides as endothelin receptor antagonists

B. Raju, Chengde Wu, Adam Kois, Erik Verner, Ilya Okun, Fiona Stavros, Ming Fai Chan

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 353 KB

english, 1996

Amide bond surrogates: A study in thiophenesulfonamide based endothelin receptor antagonists

B. Raju, Ilya Okun, Fiona Stavros, Ming Fai Chan

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 370 KB

english, 1997

Search for surrogates: A study of endothelin receptor antagonist structure activity relationships

B. Raju, Ilya Okun, Fiona Stavros, Ming Fai Chan

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 369 KB

english, 1997

2-Aryloxycarbonylthiophene-3-sulfonamides: Highly potent and etA selective endothelin receptor antagonists

B. Raju, Chengde Wu, Rosario Castillo, Ilya Okun, Fiona Stavros, Ming Fai Chan

Journal:

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Volodymyr M. Kysil, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya Okun

Année:

1997

Langue:

english

Fichier:

PDF, 354 KB

english, 1997

Synthesis and SAR of 3-arylsulfonyl-pyrazolo[1,5-a]pyrimidines as potent serotonin 5-HT6 receptor antagonists

Journal:

Dmitri V. Kravchenko, Vladimir V. Kysil, Alexey P. Ilyn, Sergey E. Tkachenko, Sergey Maliarchouk, Ilya M. Okun, Alexandre V. Ivachtchenko

Année:

2011

Langue:

english

Fichier:

PDF, 834 KB

english, 2011

1,3-Dioxo-4-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines as potent caspase-3 inhibitors

Journal:

Alexandre V. Ivachtchenko, Oleg D. Mitkin, Sergey E. Tkachenko, Ilya M. Okun, Volodymyr M. Kysil

Année:

2005

Langue:

english

Fichier:

PDF, 133 KB

english, 2005

8-Sulfonyl-substituted tetrahydro-1H-pyrido[4,3-b]indoles as 5-HT6 receptor antagonists

Journal:

European Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 499 KB

english, 2010

2-Substituted 5,6-dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrimidines: New series of highly potent and specific serotonin 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Angela G. Koryakova, Oleg D. Mitkin, Sergey E. Tkachenko, Volodymyr M. Kysil, Ilya Okun

Journal:

European Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2011

The discovery and structure—activity relationships of nonpeptide, low molecular weight antagonists selective for the endothelin ETB receptor

Ming Fai Chan, Adam Kois, Erik J. Verner, Bore G. Raju, Rosario S. Castillo, Chengde Wu, Ilya Okun, Fiona D. Stavros, V.N. Balaji

Journal:

Okun, Ilya, Veerapandian, Pandi

Année:

1998

Langue:

english

Fichier:

PDF, 1.57 MB

english, 1998

New methods to mimic nature in high-throughput screening

Journal:

Nature Biotechnology

Année:

1997

Fichier:

PDF, 743 KB

1997

Solution Phase Parallel Synthesis of Substituted 3-Phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines: Selective Serotonin 5-HT6 Receptor Antagonists

Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Koryakova, Angela G., Kovalenko, Sergiy M., Mitkin, Oleg D., Okun, Ilya M., Ravnyeyko, Irina M., Tkachenko, Sergey E., Zaremba, Oleg

Journal:

Journal of Combinatorial Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 854 KB

english, 2010

(3-Phenylsulfonylcycloalkano[e and d]pyrazolo[1,5-a]pyrimidin-2-yl)amines: Potent and Selective Antagonists of the Serotonin 5-HT6 Receptor

Ivachtchenko, Alexandre V., Dmitriev, Dmitri E., Golovina, Elena S., Kadieva, Madina G., Koryakova, Angela G., Kysil, Volodymyr M., Mitkin, Oleg D., Okun, Ilya M., Tkachenko, Sergey E., Vorobiev, Anto

Journal:

Dmitri V. Kravchenko, Volodymyr M. Kysil, Sergey E. Tkachenko, Sergey Maliarchouk, Ilya M. Okun, Alexandre V. Ivachtchenko

Année:

2010

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2010

Synthesis and caspase-3 inhibitory activity of 8-sulfonyl-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]quinolines

Journal:

Il Farmaco

Année:

2005

Langue:

english

Fichier:

PDF, 348 KB

english, 2005

Synthesis and Structure−Activity Relationship of 4-Substituted 2-(2-Acetyloxyethyl)-8-(morpholine- 4-sulfonyl)pyrrolo[3,4-c]quinoline- 1,3-diones as Potent Caspase-3 Inhibitors

Kravchenko, Dmitri V., Kuzovkova, Yulia A., Kysil, Volodymyr M., Tkachenko, Sergey E., Maliarchouk, Sergey, Okun, Ilya M., Balakin, Konstantin V., Ivachtchenko, Alexandre V.

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 215 KB

english, 2005

Discovery of TBC11251, a Potent, Long Acting, Orally Active Endothelin Receptor-A Selective Antagonist1

Wu, Chengde, Chan, Ming F., Stavros, Fiona, Raju, B., Okun, Ilya, Mong, Seymour, Keller, Karin M., Brock, Tommy, Kogan, Timothy P., Dixon, Richard A. F.

Journal:

Alexandre V. Ivachtchenko, Elena S. Golovina, Madina G. Kadieva, Volodymyr M. Kysil, Oleg D. Mitkin, Anton A. Vorobiev, Ilya Okun

Année:

1997

Langue:

english

Fichier:

PDF, 389 KB

english, 1997

Antagonists of 5-HT6 receptors. Substituted 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[3,4-e]pyrimidines and 3-(phenylsulfonyl)pyrazolo[1,5-a]pyrido[4,3-d]pyrimidines—Synthesis and ‘structure–activity’ relationship

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 985 KB

english, 2012

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3- b ]pyridine-5-carbonitriles Are Selective Inhibitors of Plasmodium falciparum Glycogen Synthase Kinase-3

Fugel, Wiebke, Oberholzer, Anselm Erich, Gschloessl, Bernhard, Dzikowski, Ron, Pressburger, Narkiss, Preu, Lutz, Pearl, Laurence H., Baratte, Blandine, Ratin, Morgane, Okun, Ilya, Doerig, Christian, K

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 4.42 MB

english, 2013

Structure−Activity Relationships of N 2 -Aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as Selective Endothelin Receptor-A Antagonists 1

Wu, Chengde, Chan, Ming F., Stavros, Fiona, Raju, B., Okun, Ilya, Castillo, Rosario S.

Journal:

Kravchenko, Dmitri V., Kysil, Volodymyr M., Ilyn, Alexey P., Tkachenko, Sergey E., Maliarchouk, Sergey, Okun, Ilya M., Ivachtchenko, Alexandre V.

Année:

1997

Langue:

english

Fichier:

PDF, 297 KB

english, 1997

Synthesis and Chemical Transformations of 6‐(Morpholine‐4‐sulfonyl)‐quinoline‐2,3,4‐tricarboxylic Acid

Journal:

Synthetic Communications

Année:

2006

Langue:

english

Fichier:

PDF, 94 KB

english, 2006

Synthesis of substituted diphenyl sulfones and their structure–activity relationship with the antagonism of 5-НТ6 receptors

Ivachtchenko, Alexandre, Golovina, Elena, Kadieva, Madina, Mitkin, Oleg, Tkachenko, Sergei, Okun, Ilya

Journal:

Ivachtchenko, Alexandre V., Golovina, Elena S., Kadieva, Madina G., Kysil, Volodymyr M., Mitkin, Oleg D., Tkachenko, Sergey E., Okun, Ilya M.

Année:

2013

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2013

Synthesis and Structure–Activity Relationship (SAR) of (5,7-Disubstituted 3-phenylsulfonyl-pyrazolo[1,5- a ]pyrimidin-2-yl)-methylamines as Potent Serotonin 5-HT 6 Receptor (5-HT 6 R) Antagonists

Journal: